Other experimental mitochondrial inhibitors for targeting CSCs Biology Diagrams Based on their mechanism of action, anti-tumor drugs that target the cell cycle can be generally divided into three categories, namely, blocking DNA synthesis, causing DNA damage, and disrupting mitotic processes. In terms of mitotic inhibitors, most compounds used in the clinic impair the normal fu โฆ Though the concept of tyrosinase activated pro-drugs has permeated the drug delivery literature for quite some time [141-143], it has yet to be applied to the delivery of mitotic kinase inhibitors. There are two themes notable in the tyrosinase pro-drug development field: attachment to DNA-damaging agents [ 142 , 144 ] and dormant compounds
Highly selective inhibitors developed against these targets showed robust cytotoxic activity in preclinical models. Similar to MT poisons, these anti-mitotics cause drug-specific and dose-dependent mitotic phenotypes through disruption of mitotic spindle morphology and MT-chromosome attachment or impairment of SAC (figure, bottom).
Mitotic inhibitor Biology Diagrams
Mitotic inhibitors are drugs derived from natural plant sources. They inhibit cell division or mitosis, where a single cell divides into two genetically identical daughter cells. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include Micromedex (updated 10
Mitosis inhibitors in anticancer therapy: When blocking the exit becomes a solution. Author links open overlay panel Ana C. Henriques a b 1, Diana Ribeiro a c 1, underlying its potential as a drug target to delay mitotic slippage [150]. The Fcp1 phosphatase dephosphorylates the kinase Wee-1, which in turn dampens Cdk1 activation,
Why Great Mitotic Inhibitors Make Poor Cancer Drugs Biology Diagrams
Secondary or acquired resistance is a result of drug treatment . Lallena MJ, de Dios A. Cyclin dependent kinase (CDK) inhibitors as anticancer drugs. Bioorg Med Chem Lett. 2015;25:3420-3435. doi: 10.1016/j.bmcl.2015.05.100. cells undergo mitotic arrest and since the compound disrupts spindle formation and
